If you're considering IVF or already in the process, you know it comes with countless decisions. One you might encounter is whether to use EmbryoGlue®. But what exactly is it, and could it improve your chances of success?

EmbryoGlue is a specialized solution used during embryo transfer that’s gaining attention for its potential to enhance implantation rates. But is it the right choice for you? Let’s break down the pros and cons so you can make an informed, confident decision.

reproductive endocrinologist describing embryoglue using an anatomical model

What’s the deal with EmbryoGlue?

First things first — despite the name, EmbryoGlue isn’t actually glue, and it’s not sticky! Think of it as a specialized solution that acts like a nurturing bath for your embryo. It’s enriched with hyaluronan, a molecule naturally found in your uterus.

Hyaluronan is believed to support implantation by helping the embryo attach to the uterine lining. In a way, it creates a welcoming, familiar environment — encouraging the embryo to settle in and stay put.

Let’s talk about benefits: What can EmbryoGlue do for you?

Understanding how EmbryoGlue works can help you decide if it’s the right choice for your IVF journey. So, let’s dive into the science behind its potential benefits.

Improved implantation rates

Some studies suggest that using EmbryoGlue can increase the chances of successful implantation, which is especially promising for those who have experienced repeated IVF failure.

Higher pregnancy rates

With better implantation comes a higher likelihood of pregnancy. Research has shown that IVF cycles using high concentrations of hyaluronic acid, like EmbryoGlue, may see improved pregnancy rates — and that’s exactly what we love to hear!

Potentially beneficial for older patients

Research also shows that EmbryoGlue could be particularly helpful for women over 35 or those with reduced embryo quality. For anyone who has felt like the odds were stacked against them, this is an encouraging possibility.

"Clinical studies have shown that using EmbryoGlue as a transfer medium enhances embryo implantation, leading to higher birth rates. Its specialized formulation, enriched with hyaluronan, provides an added advantage, offering patients a scientifically supported boost on their journey to parenthood."

— Brett Glazar, M.S.

Medical Science Liaison, North America - Vitrolife Group

fertility specialist discussing embryoglue pros and cons with patient

Things to consider: The other side of EmbryoGlue

Making an informed decision means looking at the full picture — not just the rosy parts. When it comes to IVF, being realistic and prepared is always the best approach.

Additional cost

Not all clinics offer EmbryoGlue, and among those that do, some include it in the cost of treatment while others charge extra. If you’re curious about using it, ask your fertility specialist whether it’s an option and how it might impact your IVF cycle cost. While any added expense during IVF can feel significant, EmbryoGlue — when offered — is usually a small fraction of the overall price.

No guarantees

EmbryoGlue may improve implantation and live birth rates, though success isn’t guaranteed. It’s a step that may increase your chances.

Not recommended when transferring more than one embryo

EmbryoGlue is safe for most people (unless you’re allergic to hyaluronan or gentamicin), but it’s usually not recommended if you’re transferring more than one embryo, since it can increase the chance of multiples. Depending on your goals, that might be a good thing or something to avoid — but either way, it’s a sign that EmbryoGlue may actually help with implantation.

fertility specialist prepping for an embryoglue procedure

Is EmbryoGlue right for you?

Some fertility clinics have adopted EmbryoGlue as a regular part of embryo transfer, while others use it more selectively. Like many aspects of IVF, the decision to use EmbryoGlue is personal and should be made in consultation with your fertility specialist.

It may be especially worth considering if:

  • You've experienced repeated failed implantations
  • You're over 35 or have reduced embryo quality
  • You’re okay with spending more money for a better shot at success

Speaking of IVF success…

There’s another tool worth considering: the EMMA test. It analyzes the bacteria in your uterine lining — an often-overlooked factor that plays a big role in pregnancy success.

The EMMA (Endometrial Microbiome Metagenomic Analysis) test is simple. Your provider collects a small sample — similar to a Pap smear — and sends it to a lab for advanced analysis. But here’s the cool part: instead of just detecting bacteria, EMMA identifies the specific types and their quantities.

Why does that matter? Some bacteria are essential for a healthy pregnancy, while others might make implantation more difficult — who knew?! With these insights, your provider can offer personalized recommendations to optimize your uterine environment, potentially improving your IVF success.

fertility specialist discussing embryglue pros and cons with a couple

Making a decision

IVF can feel overwhelming, and with so many factors to consider, it’s normal to feel a little uncertain. Just remember: what worked for your friend, coworker, or the celebrity you read about might not be the right path for you.

That’s why having an open, honest conversation with your fertility provider is so important. Don’t hesitate to ask questions! They’ll be able to look at your unique situation and history, helping you decide if EmbryoGlue is a good fit.

So many women and couples have been in your shoes — weighing every option, trying to figure it all out, and hoping for the best. Whether EmbryoGlue gives your embryo the extra boost it needs or the standard IVF approach is a better match, remember: you’re taking meaningful steps toward your dream of parenthood, and that’s truly amazing.

Trust your fertility team, listen to your instincts, and know that whatever choice you make is the right one for you.

Blair Sharp is a freelance writer who lives in Minnesota with her husband and son. Her words have been published in various publications, including Parents, SheKnows, The Bump, and Insider. Find her writing daily on LinkedIn and check out her weekly newsletter, Hey Freelancer! Head to her website www.blairsharp.com for more.